Vacca, Joseph P.: search on Z-Library

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1

A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors

James P. Guare, John S. Wai, Robert P. Gomez, Neville J. Anthony, Samson M. Jolly, Amanda R. Cortes, Joseph P. Vacca, Peter J. Felock, Kara A. Stillmock, William A. Schleif, Gregory Moyer, Lori J. Gab

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 159 KB

english, 2006

2

New advances in the discovery of thrombin and factor Xa inhibitors

Journal:

Current Opinion in Chemical Biology

Year:

2000

Language:

english

File:

PDF, 184 KB

english, 2000

3

Design and synthesis of HIV protease inhibitors. Variations of the carboxyterminus of the HIV protease inhibitor L-682,679

DeSolms, S. Jane, Giuliani, Elizabeth A., Guare, James P., Vacca, Joseph P., Sanders, William M., Graham, Samuel L., Wiggins, J. Mark, Darke, Paul L., Sigal, Irving S.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 772 KB

english, 1991

4

10-Hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: Potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants

Catherine M. Wiscount, Peter D. Williams, Lekhanh O. Tran, Mark W. Embrey, Thorsten E. Fisher, Vanessa Sherman, Carl F. Homnick, D. Donnette Staas, Terry A. Lyle, John S. Wai, Joseph P. Vacca, ZiQiang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 164 KB

english, 2008

5

Discovery and Evaluation of Potent P 1 Aryl Heterocycle-Based Thrombin Inhibitors

Young, Mary Beth, Barrow, James C., Glass, Kristen L., Lundell, George F., Newton, Christina L., Pellicore, Janetta M., Rittle, Kenneth E., Selnick, Harold G., Stauffer, Kenneth J., Vacca, Joseph P.,

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 350 KB

english, 2004

6

The total synthesis of D- and L-myo-inositol 1,4,5-trisphosphate

Vacca, Joseph P., DeSolms, S. Jane, Huff, Joel R.

Journal:

Journal of the American Chemical Society

Year:

1987

Language:

english

File:

PDF, 295 KB

english, 1987

7

Superior methodology for γ-lactone annulation: intramolecular : Alkoxyhydride reduction of conjugated nitriles

Peter T. Lansbury, Joseph P. Vacca

Journal:

Tetrahedron Letters

Year:

1982

Language:

english

File:

PDF, 245 KB

english, 1982

8

Novel conformationally constrained HIV-1 protease inhibitors: rational design, enzyme inhibition, and X-ray structure of an enzyme-inhibtor complex

B.Moon Kim, Joseph P. Vacca, Paula M.D. Fitzgerald, Paul L. Darke, M.Katharine Holloway, James P. Guare, Colleen M. Hanifin, Deborah J. Arford-Bickerstaff, Joan A. Zugay, Jenny M. Wai, Paul S. Anderso

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 2.01 MB

english, 1994

9

Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures: Rapid Structure−Activity Studies by Solid-Phase Synthesis

Lumma,, William C., Witherup, Keith M., Tucker, Thomas J., Brady, Steven F., Sisko, John T., Naylor-Olsen, Adel M., Lewis, S. Dale, Lucas, Bobby J., Vacca, Joseph P.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 83 KB

english, 1998

10

Substituted alkylpyridines as P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors: Improved pharmacokinetic profiles

B. Moon Kim, Colleen M. Hanifin, C. Blair Zartman, Joseph P. Vacca, Stuart R. Michelson, Jiunn H. Lin, I.-W. Chen, Kari Vastag, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Paul S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 277 KB

english, 1995

11

Conformationally biased P3 amide replacements of β-secretase inhibitors

Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele, Min-Chi Crouthamel, Beth L. Pietrak, Ming-Tain Lai, M. Katharine Holloway, Sanjeev K. Munshi, Samuel L. Graham, Joseph P. Vacca

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 162 KB

english, 2006

12

N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-yl)-N-methyl-2-hydroxyethanesulfonamide: a potent and selective .alpha.2-adrenoceptor antagonist

Huff, Joel R., Anderson, Paul S., Baldwin, John J., Clineschmidt, Bradley V., Guare, James P., Lotti, Victor J., Pettibone, Douglas J., Randall, William C., Vacca, Joseph P.

Journal:

Journal of Medicinal Chemistry

Year:

1985

Language:

english

File:

PDF, 542 KB

english, 1985

13

Clinical evaluation of acetyl-digitoxin

Joseph B. Vacca, Joseph M. Schuster, William A. Knight Jr.

Journal:

The American Journal of Cardiology

Year:

1958

Language:

english

File:

PDF, 569 KB

english, 1958

14

P4-187 Development of BACE 1 inhibitors

Brady, Stephen, Bruce, James, Singh, Satendra, Crouthamel, Ming-Chih, Holoway, Katharine M., Coburn, Craig, Vacca, Joseph P., Shafer, Jules A., Hazuda, Daria, Lai, Ming-Tain

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 162 KB

english, 2004

15

A Priori Prediction of Activity for HIV-1 Protease Inhibitors Employing Energy Minimization in the Active Site

Holloway, M. Katharine, Wai, Jenny M., Halgren, Thomas A., Fitzgerald, Paula M. D., Vacca, Joseph P., Dorsey, Bruce D., Levin, Rhonda B., Thompson, Wayne J., Chen, L. Jenny, deSolms, S. Jane, Gaffin,

Journal:

Journal of Medicinal Chemistry

Year:

1996

File:

PDF, 17 KB

1996

16

Metabolite–P450 Complex Formation by Methylenedioxyphenyl HIV Protease Inhibitors in Rat and Human Liver Microsomes

Masato Chiba, Joy A Nishime, I-Wu Chen, Kari J Vastag, Yousif S Sahly, Byeong Moon Kim, Bruce D Dorsey, Joseph P Vacca, Jiunn H Lin

Journal:

Biochemical Pharmacology

Year:

1998

Language:

english

File:

PDF, 539 KB

english, 1998

17

ROUND-UP Service Delivery

Brady, Stephen, Bruce, James, Singh, Satendra, Crouthamel, Ming-Chih, Holoway, Katharine M., Coburn, Craig, Vacca, Joseph P., Shafer, Jules A., Hazuda, Daria, Lai, Ming-Tain

Journal:

Reproductive Health Matters

Year:

2001

Language:

english

File:

PDF, 627 KB

english, 2001

18

The structural water of fibrin molecules measured by heat drying and compared with derivations from electron microscopic molecular models

Günter Köppel, Joseph G. Vacca

Journal:

Cell and Tissue Research

Year:

1974

Language:

english

File:

PDF, 2.14 MB

english, 1974

19

SPIE Proceedings [SPIE 18th Annual BACUS Symposium on Photomask Technology and Management - Redwood City, CA (Wednesday 16 September 1998)] 18th Annual BACUS Symposium on Photomask Technology and Management - Defect inspection capability for advanced OPC photomasks

Straub, Joseph A., Vacca, Anthony, Zurbrick, Larry S., Grenon, Brian J., Abboud, Frank E.

Year:

1998

Language:

english

File:

PDF, 2.53 MB

english, 1998

20

[Methods in Enzymology] Retroviral proteases Volume 241 || [17] Design of tight-binding human immunodeficiency virus type 1 protease inhibitors

Vacca, Joseph P.

Year:

1994

Language:

english

File:

PDF, 7.97 MB

english, 1994

21

Cycloalkylpiperazines as HIV-1 protease inhibitors: enhanced oral absorption

B. Moon Kim, Ben E. Evans, Kevin F. Gilbert, Colleen M. Hanifin, Joseph P. Vacca, Stuart R. Michelson, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Jiunn H. Lin, I.-W. Chen, Kari Va

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 287 KB

english, 1995

22

Epsilon substituted lysinol derivatives as HIV-1 protease inhibitors

Kristen L.G. Jones, M. Katharine Holloway, Hua-Poo Su, Steven S. Carroll, Christine Burlein, Sinoeun Touch, Daniel J. DiStefano, Rosa I. Sanchez, Theresa M. Williams, Joseph P. Vacca, Craig A. Coburn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 714 KB

english, 2010

23

Thiophene derivatives as extremely high affinity P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors

B. Moon Kim, James P. Guare, Joseph D. Vacca, Stuart R. Michelson, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Jiunn H. Lin, I.W. Chen, Kari Vastag, Paul S. Anderson, Joel R. Huff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 297 KB

english, 1995

24

Structure-affinity relationships of arylquinolizines at .alpha.-adrenoceptors

Huff, Joel R., Baldwin, John J., DeSolms, S. Jane, Guare, James P., Hunt, Cecilia A., Randall, William C., Sanders, William S., Smith, Steven J., Vacca, Joseph P., Zrada, Matthew M.

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 658 KB

english, 1988

25

SPIE Proceedings [SPIE 15th European Conference on Mask Technology for Integrated Circuits and Micro-Components - Munich, Germany (Monday 16 November 1998)] 15th European Conference on Mask Technology for Integrated Circuits and Microcomponents '98 - Characterization of inspection sensitivity on advanced OPC reticles

Zurbrick, Larry S., Straub, Joseph A., Vacca, Anthony, Behringer, Uwe F. W.

Year:

1999

Language:

english

File:

PDF, 1.66 MB

english, 1999

26

A Kinetic Isotope Effect and Isotope Exchange Study of the Nonenzymatic and the Equine Serum Butyrylcholinesterase-Catalyzed Thioester Hydrolysis

Robins, Lori I., Meisenheimer, Kristen M., Fogle, Emily J., Chaplan, Cory A., Redman, Richard L., Vacca, Joseph T., Tellier, Michelle R., Collins, Brittney R., Duong, Dorothea H., Schulz, Kathrin, Mar

Journal:

Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 679 KB

english, 2013

27

The total synthesis of myo-inositol phosphates via myo-inositol orthoformate

Billington, David C., Baker, Raymond, Kulagowski, Janusz J., Mawer, Ian M., Vacca, Joseph P., deSolms, S. Jane, Huff, Joel R.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1989

Language:

english

File:

PDF, 910 KB

english, 1989

28

What reading strategies make sense to content area teachers?

Criscuolo, Nicholas P., Vacca, Richard T., LaVorgna, Joseph J.

Journal:

Year:

1980

Language:

english

File:

PDF, 314 KB

english, 1980

29

Editorial [Hot Topic:Alzheimers Disease (Guest Editors: Shawn J. Stachel & Joseph P. Vacca)]

Stachel, Shawn, Vacca, Joseph

Journal:

Current Topics in Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 17 KB

english, 2006

30

Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors

H. Marie Langford, Peter D. Williams, Carl F. Homnick, Joseph P. Vacca, Peter J. Felock, Kara A. Stillmock, Marc V. Witmer, Daria J. Hazuda, Lori J. Gabryelski, William A. Schleif

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 140 KB

english, 2008

31

Aromatic P1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN®

Craig A. Coburn, Mary Beth Young, Randall W. Hungate, Richard C.A. Isaacs, Joseph P. Vacca, Joel R. Huff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 164 KB

english, 1996

32

Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells

Zhuang, Linghang, Wai, John S., Embrey, Mark W., Fisher, Thorsten E., Egbertson, Melissa S., Payne, Linda S., Guare,, James P., Vacca, Joseph P., Hazuda, Daria J., Felock, Peter J., Wolfe, Abigail L.,

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 80 KB

english, 2003

33

A potent and orally active HIV-1 integrase inhibitor

Melissa S. Egbertson, H. Marie Moritz, Jeffrey Y. Melamed, Wei Han, Debra S. Perlow, Michelle S. Kuo, Mark Embrey, Joseph P. Vacca, Matthew M. Zrada, Amanda R. Cortes, Audrey Wallace, Yvonne Leonard,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 256 KB

english, 2007

34

Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality

Michael R. Wood, Kathy M. Schirripa, June J. Kim, Rodney A. Bednar, John F. Fay, Joseph G. Bruno, Eric L. Moore, Scott D. Mosser, Shane Roller, Christopher A. Salvatore, Joseph P. Vacca, Harold G. Sel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 719 KB

english, 2010

35

Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability

Matthew M Morrissette, Kenneth J Stauffer, Peter D Williams, Terry A Lyle, Joseph P Vacca, Julie A Krueger, S.Dale Lewis, Bobby J Lucas, Bradley K Wong, Rebecca B White, Cynthia Miller-Stein, Elizabet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 283 KB

english, 2004

36

Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: Development of novel spiropiperidines

Christopher S. Burgey, Craig M. Potteiger, James Z. Deng, Scott D. Mosser, Christopher A. Salvatore, Sean Yu, Shane Roller, Stefanie A. Kane, Joseph P. Vacca, Theresa M. Williams

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 707 KB

english, 2009

37

Synthesis and evaluation of pyridyl analogs of L-735,524: Potent HIV-1 protease inhibitors

Bruce D. Dorsey, Stacey L. McDaniel, Rhonda B. Levin, Joseph P. Vacca, Paul L. Darke, Joan A. Zuga, Emilio A. Emini, William A. Schleif, Jiunn H. Lin, I-W. Chen, M.Katharine Holloway, Paul S. Anderson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 406 KB

english, 1994

38

The total synthesis of myo-inositol polyphosphates

Joseph P. Vacca, S.Jane deSolms, Joel R. Huff, David C. Billington, Raymond Baker, Janusz J. Kulagowski, Ian M. Mawer

Journal:

Year:

1989

Language:

english

File:

PDF, 1.52 MB

english, 1989

39

Clinically effective HIV-1 protease inhibitors

Joseph P. Vacca, Jon H. Condra

Journal:

Drug Discovery Today

Year:

1997

Language:

english

File:

PDF, 1.25 MB

english, 1997

40

A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells

Mark W. Embrey, John S. Wai, Timothy W. Funk, Carl F. Homnick, Debbie S. Perlow, Steven D. Young, Joseph P. Vacca, Daria J. Hazuda, Peter J. Felock, Kara A. Stillmock, Marc V. Witmer, Gregory Moyer, W

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 145 KB

english, 2005

41

SOFIA /FORCAST AND SPITZER /IRAC IMAGING OF THE ULTRACOMPACT H II REGION W3(OH) AND ASSOCIATED PROTOSTARS IN W3

Hirsch, Lea, Adams, Joseph D., Herter, Terry L., Hora, Joseph L., De Buizer, James M., Megeath, S. Thomas, Gull, George E., Henderson, Charles P., Keller, Luke D., Schoenwald, Justin, Vacca, William

Journal:

The Astrophysical Journal

Year:

2012

Language:

english

File:

PDF, 749 KB

english, 2012

42

A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailability

B.Moon Kim, Joseph P. Vacca, James P. Guare, Colleen M. Hanifin, Stuart R. Michelson, PaulL. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Jiunn H. Lin, I-Wu Chen, Kari Vastag, Drazen Ostovi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 463 KB

english, 1994

43

The total synthesis of (±)-myo-inositol-1,3,4-trisphosphate, (±)-myo-inositol-2,4,5-trisphosphate and (±)-myo-inositol-1,3,4,5-tetrakisphosphate

S.Jane deSolms, Joseph P. Vacca, Joel R. Huff

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 201 KB

english, 1987

44

FIRST SCIENCE RESULTS FROM SOFIA/FORCAST: SUPER-RESOLUTION IMAGING OF THE S140 CLUSTER AT 37 μm

Harvey, Paul M., Adams, Joseph D., Herter, Terry L., Gull, George, Schoenwald, Justin, Keller, Luke D., De Buizer, James M., Vacca, William, Reach, William, Becklin, E. E.

Journal:

The Astrophysical Journal

Year:

2012

Language:

english

File:

PDF, 545 KB

english, 2012

45

[Annual Reports in Medicinal Chemistry] Volume 33 || Thrombosis and Coagulation

Vacca, Joseph P.

Year:

1998

Language:

english

File:

PDF, 719 KB

english, 1998

46

Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold

Peter D. Williams, Donnette D. Staas, Shankar Venkatraman, H. Marie Loughran, Rowena D. Ruzek, Theresa M. Booth, Terry A. Lyle, John S. Wai, Joseph P. Vacca, Bradley P. Feuston, Linda T. Ecto, Jessica

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 320 KB

english, 2010

47

A convergent synthesis of novel conformationally restricted HIV-1 protease inhibitors

B.Moon Kim, James P. Guare, Colleen M. Hanifin, Deborah J. Arford-Bickerstaff, Joseph P. Vacca, Richard G. Ball

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 353 KB

english, 1994

48

Identification of a novel RAMP-independent CGRP receptor antagonist

C. Blair Zartman, Ian M. Bell, Steven N. Gallicchio, Samuel L. Graham, Stefanie A. Kane, John J. Mallee, Ruth Z. Rutledge, Christopher A. Salvatore, Joseph P. Vacca, Theresa M. Williams

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 500 KB

english, 2011

49

Approaches Toward New Alzheimer's Treatments

Vacca, Joseph P.

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 126 KB

english, 2012

50

A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site

Holloway, M. Katharine, Wai, Jenny M., Halgren, Thomas A., Fitzgerald, Paula M. D., Vacca, Joseph P., Dorsey, Bruce D., Levin, Rhonda B., Thompson, Wayne J., Chen, L. Jenny

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 3.73 MB

english, 1995

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